Article

Human papillomavirus 16 E2 regulates keratinocyte gene expression relevant to cancer and the viral life cycle

2018-11-05

Abstract excerpt

Human papillomaviruses (HPV) are causative agents in ano-genital and oropharyngeal cancers. The virus must reprogram host gene expression to promote infection, and E6 and E7 contribute to this via targeting of cellular transcription factors including p53 and pRb, respectively. The HPV16 E2 protein regulates host gene expression in U2OS cells and in this study we extend these observations into TERT immortalized ora...

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Literature Corpus work: f5f6313e-3074-513f-ae7f-f411b8a01c25
DOI: 10.1101/461715

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