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Human Papillomavirus 16 E6 and E7 Synergistically Repress Innate Immune Gene Transcription

7 Jan 2020

Abstract excerpt

The role of human papillomavirus 16 (HPV16) in human cancers is well established; however, to date there are no antiviral therapeutics that are available for combatting these cancers. To identify such targets, we must enhance the understanding of the viral life cycle. Innate immune genes (IIGs) are repressed by HPV16, and we have reported that this repression persists through to cancer. Reversal of this...

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PMID: 31915229
DOI: 10.1128/msphere.00828-19

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