Article

Epigenetic–metabolic axis in the temporal scaling of mammalian cortical neurogenesis across species

2025-09-24

Abstract excerpt

Developmental timescales vary widely across species, with mammalian cortical neurogenesis ranging from just days to several months. Given the conserved laminar architecture and regulatory gene expression sequences, the underlying molecular mechanisms controlling neurogenesis rate remain unknown. Using mouse, ferret, and human models, we combined comparative transcriptomics with mathematical modelling to identify c...

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Literature Corpus work: b47fc16e-9c19-5074-8acd-9af2db0e0acb
DOI: 10.1101/2025.09.23.677958

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