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Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling

12 Sept 2019

Abstract excerpt

Organoid technologies have become a powerful emerging tool to model liver diseases, for drug screening, and for personalized treatments. These applications are, however, limited in their capacity to generate functional hepatocytes in a reproducible and efficient manner. Here, we generated and characterized the hepatic organoid (eHEPO) culture system using human induced pluripotent stem cell (iPSC)-derived...

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PMID: 31522975
DOI: 10.1016/j.stemcr.2019.08.007

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