Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype

10 Sept 2020

Abstract excerpt

Significance As the recall of CD8 + T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific CD8 + T cells from COVID-19 patients. For two HLA-A*02:01 SARS-CoV-2−specific CD8 + T cell epitopes, we found that, while ex vivo frequencies of responding T cells were approximately fivefold higher than for pre−COVID-19 samples, they were ∼10-fold lower than for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Immunotherapy and Immune Responses
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32913053
DOI: 10.1073/pnas.2015486117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotypePMID 32913053Read ↗

Suboptimal SARS-CoV-2-specific CD8<sup>+</sup> T-cell response associated with the prominent HLA-A*02:01 phenotypeSemantic proximity Read ↗

Distinct CD8 <sup>+</sup> T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2 <sup>+</sup> PatientsSemantic proximity Read ↗

Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19Semantic proximity Read ↗

HLA-B*15:01-positive severe COVID-19 patients lack CD8 + T cell pools with highly expanded public clonotypesSemantic proximity Read ↗

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cellsSemantic proximity Read ↗

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.Semantic proximity Read ↗

Parallel detection of SARS‐CoV ‐2 epitopes reveals dynamic immunodominance profiles of CD8 + T memory cells in convalescent COVID ‐19 donorsSemantic proximity Read ↗

Serial vaccination expands and refines human CD4 <sup>+</sup> T cell memorySemantic proximity Read ↗

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.Semantic proximity Read ↗

SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigensSemantic proximity Read ↗

Recruitment of highly functional SARS-CoV-2-specific CD8 <sup>+</sup> T cell receptors mediating cytotoxicity of virus-infected target cells in non-severe COVID-19Semantic proximity Read ↗

CD8 <sup>+</sup> T cell signature in acute SARS-CoV-2 infection identifies memory precursorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.