Back to search

Article

Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 <sup>+</sup> T-cells reveal strong functional impairment and recognition bias as markers for disease severity

2025-03-26

Abstract excerpt

CD8 + T-cells are essential for controlling and resolving SARS-CoV-2 infection, yet their antigen-specific resolution in relation to disease severity, functional dynamics during acute infection, and long-term memory formation remain incompletely understood. Using comprehensive longitudinal profiling of 553 SARS-CoV-2 immunogenic antigens across globally prevalent HLAs, we identified antigen-specific CD8 + T-cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
95f4613d-4326-5b8a-b3ad-0ce0cf2f049f
DOI
10.1101/2025.03.25.644515
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comprehensive longitudinal profiling of SARS-CoV-2-specific CD8 <sup>+</sup> T-cells reveal strong functional impairment and recognition bias as markers for disease severityDOI 10.1101/2025.03.25.644515
Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features.Semantic proximity
Distinct CD8 <sup>+</sup> T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2 <sup>+</sup> PatientsSemantic proximity
Recruitment of highly cytotoxic CD8+ T cell receptors in mild SARS-CoV-2 infectionSemantic proximity
Recruitment of highly functional SARS-CoV-2-specific CD8 <sup>+</sup> T cell receptors mediating cytotoxicity of virus-infected target cells in non-severe COVID-19Semantic proximity
Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofilingSemantic proximity
Immune Features of COVID-19 Convalescent Individuals Revealed by a Single-cell RNA SequencingSemantic proximity
Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8 <sup>+</sup> T cell repertoire upon viral exposureSemantic proximity
A unique cytotoxic CD4<sup>+</sup>T cells signature defines critical COVID-19Semantic proximity
A unique cytotoxic CD4 + T cell‐signature defines critical COVID‐19Semantic proximity
Severely ill COVID-19 patients display augmented functional properties in SARS-CoV-2-reactive CD8 <sub>+</sub> T cellsSemantic proximity
COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patientsSemantic proximity
Select a neighboring publication to make it the new centre.