CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.

doi:10.1016/j.immuni.2021.04.009

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Article

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.

Immunity - 11 May 2021

Nguyen Thi H O, Rowntree Louise C, Petersen Jan, Chua Brendon Y, Hensen Luca, Kedzierski Lukasz, van de Sandt Carolien E, Chaurasia Priyanka, Tan Hyon-Xhi, Habel Jennifer R, Zhang Wuji, Allen Lilith F, Earnest Linda, Mak Kai Yan, Juno Jennifer A, Wragg Kathleen, Mordant Francesca L, Amanat Fatima, Krammer Florian, Mifsud Nicole A, Doolan Denise L, Flanagan Katie L, Sonda Sabrina, Kaur Jasveen, Wakim Linda M, Westall Glen P, James Fiona, Mouhtouris Effie, Gordon Claire L, Holmes Natasha E, Smibert Olivia C, Trubiano Jason A, Cheng Allen C, Harcourt Peter, Clifton Patrick, Crawford Jeremy Chase, Thomas Paul G, Wheatley Adam K, Kent Stephen J, Rossjohn Jamie, Torresi Joseph, Kedzierska Katherine

Abstract excerpt

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cells. By using peptide-human leukocyte antigen (HLA) tetramers for direct ex vivo analysis, we characterized CD8+ T cells specific for SARS-CoV-2 epitopes in COVID-19 patients and unexposed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to CD8-Positive T-Lymphocytes

Share to Coronavirus Nucleocapsid Proteins

Share to Epitopes, T-Lymphocyte

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Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 33951417
DOI: 10.1016/j.immuni.2021.04.009
PMCID: PMC8049468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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