Article

p53 Biology and Reactivation for Improved Therapy in MDS and AML–Are We Building Castles in the Air?

2023-09-13

Abstract excerpt

Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) originate from preleukemic hematopoietic conditions, such as clonal hematopoiesis of indeterminate potential (CHIP) or clonal cytopenia of undetermined significance (CCUS) and have desolate outcomes. The prognosis is worse in patients with TP53 mutations which are often linked to complex karyotypes and contribute to worse responses to induction therap...

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Literature Corpus work: 092f4f78-2c29-5e23-aa6d-bdbdec63a5fd
DOI: 10.20944/preprints202309.0848.v1

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