Article

Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation

2025-02-07

Abstract excerpt

<h4>Backgrounds: </h4> and aims: SNX27, member of the sorting nexin (SNX) family, carries a unique PDZ domain and mediates recycling of endocytosed transmembrane proteins. SNX27 is critical for neurodevelopmental processes, however its role in intestine remains unexplored. We aim to determine the previously unknown roles of SNX27 in regulating intestinal homeostasis, epithelial barrier integrity, and inflammatory...

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Literature Corpus work: b8e5db68-bba8-5a3b-9c6c-51fad4c023c9
DOI: 10.1101/2025.02.05.635995

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