Article

Chaperone-assisted cryo-EM structure of <i>P. aeruginosa</i> PhuR reveals molecular basis for heme binding

2023-08-01

Abstract excerpt

<h4>SUMMARY</h4> Pathogenic bacteria, such as Pseudomonas aeruginosa , depend on scavenging heme for the acquisition of iron, an essential nutrient. The TonB-dependent transporter (TBDT) PhuR is the major heme uptake protein in P. aeruginosa clinical isolates. However, a comprehensive understanding of heme recognition and TBDT transport mechanisms, especially PhuR, remains limited. In this study, we employed si...

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Literature Corpus work: b8d236a5-15b9-5d21-af9f-e85be97a1d53
DOI: 10.1101/2023.08.01.551527

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