Article

Establishment and characterization of multiple myeloma cell lines from a single patient’s disease course immortalizes clonal heterogeneity

2026-03-12

Abstract excerpt

<title>Abstract</title> <p>Multiple myeloma (MM) is an incurable plasma cell neoplasm characterized by diverse and complex genetic abnormalities, including translocations of immunoglobulin (Ig) genes and a hyperdiploid (HRD) karyotype. Much of our current understanding of MM genetics, epigenetics, pathogenesis and response/resistance to myeloma directed therapies originated from studies on human MM-derived cell l...

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Literature Corpus work: 0503158f-7121-5bdd-acca-4f622be1fb96
DOI: 10.21203/rs.3.rs-9003051/v1

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