Article

VCP functions to maintain nuclear size by managing DNA damage-induced MDC1–p53–autophagy axis

2020-08-12

Abstract excerpt

Anomalies in nuclear morphology have been linked to aging-related diseases and malignant transformation, although the mechanism responsible for this connection remains unclear. By expressing dominant-negative TER94 (TER94K2A) mutants in Drosophila photoreceptors, we show disruption of VCP (valosin-containing protein, TER94 ortholog in human), an AAA (ATPase associated with various cellular activities) ATPase essen...

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Literature Corpus work: b890a163-4be3-559a-ac17-4fff2550147b
DOI: 10.21203/rs.3.rs-49185/v1

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