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Article

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration.

Cell death and differentiation - 1 Mar 2002

Higashiyama H, Hirose F, Yamaguchi M, Inoue Y H, Fujikake N, Matsukage A, Kakizuka A

Abstract excerpt

We have successfully generated a Drosophila model of human polyglutamine (polyQ) diseases by the targeted expression of expanded-polyQ (ex-polyQ) in the Drosophila compound eye. The resulting eye degeneration is progressive and ex-polyQ dosage- and ex-polyQ length-dependent. Furthermore, intergenerational changes in repeat length were observed in homozygotes, with concomitant changes in the levels of...

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Source

Identifiers

PMID: 11859409
DOI: 10.1038/sj.cdd.4400955

Genes

VCP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration.PMID 11859409Read ↗

Loss of function of VCP/TER94 causes neurodegeneration.Semantic proximity Read ↗

VCP functions to maintain nuclear size by managing DNA damage-induced MDC1–p53–autophagy axisSemantic proximity Read ↗

Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis.Semantic proximity Read ↗

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.Semantic proximity Read ↗

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.Semantic proximity Read ↗

TER94 , the Drosophila Homologue of the ALS-related VCP gene, Influences Lifespan and Leads to a Decline in Motor FunctionSemantic proximity Read ↗

Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.Semantic proximity Read ↗

Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.Semantic proximity Read ↗

Expanded polyQ aggregates interact with Sarco-endoplasmic reticulum calcium ATPase and Drosophila Inhibitor of Apoptosis Protein1 to regulate polyQ mediated neurodegeneration in DrosophilaSemantic proximity Read ↗

Age-dependent dynamics of neuronal VAPB <sup>ALS</sup> inclusions in the adult brainSemantic proximity Read ↗

Control of rapsyn stability by the CUL-3-containing E3 ligase complex.Semantic proximity Read ↗

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.Semantic proximity Read ↗

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