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Article

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration.

Cell death and differentiation - 1 Mar 2002

Higashiyama H, Hirose F, Yamaguchi M, Inoue Y H, Fujikake N, Matsukage A, Kakizuka A

Abstract excerpt

We have successfully generated a Drosophila model of human polyglutamine (polyQ) diseases by the targeted expression of expanded-polyQ (ex-polyQ) in the Drosophila compound eye. The resulting eye degeneration is progressive and ex-polyQ dosage- and ex-polyQ length-dependent. Furthermore, intergenerational changes in repeat length were observed in homozygotes, with concomitant changes in the levels of...

Topics

Adenosine Triphosphatases
Animals
Apoptosis
Cell Cycle Proteins
Disease Models, Animal
Drosophila Proteins
Drosophila melanogaster
Eye
Mutation
Neurodegenerative Diseases
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Trinucleotide Repeats

Valosin Containing Protein

Source

Identifiers

PMID: 11859409
DOI: 10.1038/sj.cdd.4400955

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration.PMID 11859409Read ↗

Loss of function of VCP/TER94 causes neurodegeneration.Semantic proximity Read ↗

VCP functions to maintain nuclear size by managing DNA damage-induced MDC1–p53–autophagy axisSemantic proximity Read ↗

Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis.Semantic proximity Read ↗

Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.Semantic proximity Read ↗

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.Semantic proximity Read ↗

TER94 , the Drosophila Homologue of the ALS-related VCP gene, Influences Lifespan and Leads to a Decline in Motor FunctionSemantic proximity Read ↗

Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.Semantic proximity Read ↗

Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.Semantic proximity Read ↗

Expanded polyQ aggregates interact with Sarco-endoplasmic reticulum calcium ATPase and Drosophila Inhibitor of Apoptosis Protein1 to regulate polyQ mediated neurodegeneration in DrosophilaSemantic proximity Read ↗

Age-dependent dynamics of neuronal VAPB <sup>ALS</sup> inclusions in the adult brainSemantic proximity Read ↗

Control of rapsyn stability by the CUL-3-containing E3 ligase complex.Semantic proximity Read ↗

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.Semantic proximity Read ↗

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