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Article

Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease.

Neuron - 4 Mar 2026

Dubey Sandeep Kumar, Chaubey Divya, Ikenaga Chiseko, Lin Wen-Wen, Bellen Hugo J, Lloyd Thomas E

Abstract excerpt

Defective nucleocytoplasmic transport (NCT) has emerged as a contributing factor in the pathogenesis of neurodegenerative diseases and aging. Valosin-containing protein (VCP) is an AAA+ATPase required for disassembly of protein complexes, and mutations in VCP cause neurodegenerative and neuromuscular diseases. We find that VCP is required for quality control of nuclear pore complexes (NPCs) by extracting selected...

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Source

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Identifiers

PMID: 41475349
DOI: 10.1016/j.neuron.2025.11.017
PMCID: PMC13123404

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Aberrant nuclear pore complex degradation contributes to neurodegeneration in VCP disease.PMID 41475349Read ↗

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