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Article

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma

1 Feb 2018

Abstract excerpt

Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ , GNA11 , CYSLTR2 , and PLCB4 , four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11 Q209L with and without homozygous Bap1 loss. The GNA11 Q209L mice recapitulated human Gq-associated melanomas, and...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 29490280
DOI: 10.1016/j.celrep.2018.01.081

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