Article
[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches].
Molekuliarnaia biologiia - 1 Jan 2024
Zhilnikova M V, Troitskaya O S, Novak D D, Atamanov V V, Koval O A
Abstract excerpt
Uveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, including the iris, the ciliary body, and the choroid. UM accounts for 5% of all melanoma cases and is extremely aggressive with half of the UM patients developing metastases within the first 1-2 years after tumor development. Molecular mechanisms of UM carcinogenesis are poorly understood,...
Topics
- Humans
- Uveal Neoplasms
- Melanoma
- Mutation
- GTP-Binding Protein alpha Subunits
- Neoplasm Proteins
- Ubiquitin Thiolesterase
- GTP-Binding Protein alpha Subunits, Gq-G11
- Signal Transduction
- Tumor Suppressor Proteins