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[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches].

Molekuliarnaia biologiia - 1 Jan 2024

Zhilnikova M V, Troitskaya O S, Novak D D, Atamanov V V, Koval O A

Abstract excerpt

Uveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, including the iris, the ciliary body, and the choroid. UM accounts for 5% of all melanoma cases and is extremely aggressive with half of the UM patients developing metastases within the first 1-2 years after tumor development. Molecular mechanisms of UM carcinogenesis are poorly understood,...

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Identifiers

PMID: 39355878
DOI: 10.31857/S0026898424020017

Genes

GNA11
GNAQ
BAP1
EIF1AX
SF3B1

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