Article

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

2023-04-14

Abstract excerpt

<h4>SUMMARY</h4> The SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD); however, definitive evidence for the importance of SEL1L in HRD1 ERAD is lacking. Here we report that attenuation of the interaction between SEL1L and HRD1 impairs HRD1 ERAD function and has pathological consequences in mice. Our data show that SEL1L variant p.Ser658P...

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Literature Corpus work: 28bf8d07-50ec-5247-ba41-52cc3432567b
DOI: 10.1101/2023.04.13.536796

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