Article

Functional integrity of the SEL1L-HRD1 complex is critical for ERAD and organismal viability

2025-08-02

Abstract excerpt

<h4>ABSTRACT</h4> The SEL1L-HRD1 complex represents the most evolutionarily conserved branch of endoplasmic reticulum-associated degradation (ERAD), with SEL1L acting as a key cofactor for the E3 ubiquitin ligase HRD1. While the physiological relevance of this complex has been increasingly recognized, whether SEL1L is strictly required for HRD1 function in mammals has remained unclear. Here, using complementary...

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Literature Corpus work: 82e2ea46-2934-5c76-817e-c267d0e5cd82
DOI: 10.1101/2025.08.01.668162

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