Article

Decoding Prognostic Markers: Bioinformatics Insights into PIH1D1 and p53 in Children’s Brain Cancer

2023-12-11

Abstract excerpt

Genetic alterations in normal brain cells lead to the development of brain tumors (BT). The incidence of newly diagnosed cases is on the rise over time. Understanding the molecular biology of pediatric brain tumors is crucial for advancing novel therapeutic approaches to prevent or effectively manage this disease. The R2TP complex, a conserved co-chaperone from yeast to mammals, including RUVBL1, RUVBL2, PIH1D1, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8287d3d-8999-565b-a742-ad76053a7621
DOI: 10.1101/2023.12.09.570938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Decoding Prognostic Markers: Bioinformatics Insights into PIH1D1 and p53 in Children’s Brain CancerDOI 10.1101/2023.12.09.570938Read

Improving Diagnostic and Therapeutic Outcomes in Pediatric Brain Tumors.Semantic proximity Read

Unraveling the genetic and singaling landscapes of pediatric cancer.Semantic proximity Read

OpenPBTA: An Open Pediatric Brain Tumor AtlasSemantic proximity Read

Revolutionizing pediatric neuroblastoma treatment: unraveling new molecular targets for precision interventionsSemantic proximity Read

The Children’s Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open ScienceSemantic proximity Read

Hijacking a neurodevelopmental epigenomic program in metastatic dissemination of medulloblastomaSemantic proximity Read

De novo variants disrupt an LDB1 -regulated transcriptional network in congenital ventriculomegalySemantic proximity Read

Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors.Semantic proximity Read

The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.Semantic proximity Read

Hypoxia-induced regulation of zDHHC23 opens avenues for new biomarkers for NON MYCN-amplified neuroblastomaSemantic proximity Read

Neurodevelopmental Disorders: From Genetics to Functional Pathways.Semantic proximity Read

In-depth Inference of Transcriptional Regulatory Networks Identifies NPM1 as a Druggable Master Regulator in MedulloblastomaSemantic proximity Read