Article

Fas-threshold signalling in MSCs causes tumour progression and metastasis

2020-12-03

Abstract excerpt

Mesenchymal stem cells (MSCs) are part of the tumour microenvironment and have been implicated in tumour progression. We found the number of MSCs significantly increased in tumour-burdened mice driven by Fas-threshold signalling. Consequently, MSCs lacking Fas lost their ability to induce metastasis development in a pancreatic cancer model. Mixing of MSCs with pancreatic cancer cells led to sustained production of...

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Literature Corpus work: b80de053-c2a1-5d1c-bcf2-b3cd9786e3b7
DOI: 10.1101/2020.12.02.406918

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