Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.

doi:10.1038/s41467-020-18701-4

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Article

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.

Nature communications - 5 Oct 2020

Werner-Klein Melanie, Grujovic Ana, Irlbeck Christoph, Obradović Milan, Hoffmann Martin, Koerkel-Qu Huiqin, Lu Xin, Treitschke Steffi, Köstler Cäcilia, Botteron Catherine, Weidele Kathrin, Werno Christian, Polzer Bernhard, Kirsch Stefan, Gužvić Miodrag, Warfsmann Jens, Honarnejad Kamran, Czyz Zbigniew, Feliciello Giancarlo, Blochberger Isabell, Grunewald Sandra, Schneider Elisabeth, Haunschild Gundula, Patwary Nina, Guetter Severin, Huber Sandra, Rack Brigitte, Harbeck Nadia, Buchholz Stefan, Rümmele Petra, Heine Norbert, Rose-John Stefan, Klein Christoph A

Abstract excerpt

Although thousands of breast cancer cells disseminate and home to bone marrow until primary surgery, usually less than a handful will succeed in establishing manifest metastases months to years later. To identify signals that support survival or outgrowth in patients, we profile rare bone marrow-derived disseminated cancer cells (DCCs) long before manifestation of metastasis and identify IL6/PI3K-signaling as...

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Identifiers

PMID: 33020483
DOI: 10.1038/s41467-020-18701-4
PMCID: PMC7536220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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