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Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.

2023-08-23

Abstract excerpt

<title>Abstract</title> <p>In the tumor hypoxic environment, three isoforms of hypoxia-inducible factor (HIF)-α activates transcription of genes critical in the adaptive response to low oxygen levels in mammals. Most studies have focused on HIF-1α and HIF-2α, but not HIF-3α. Using RNA-seq, we found that overexpression of HIF-3α1 in colorectal cancer cells resulted in a gene signature of epithelial-mesenchymal tra...

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Literature Corpus work
b8077c89-4e62-5969-8a53-28f90aa9031e
DOI
10.21203/rs.3.rs-3282109/v1
Open publication

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Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.DOI 10.21203/rs.3.rs-3282109/v1
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