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Article

Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases.

Annals of surgical oncology - 1 Dec 2013

Shimomura Manabu, Hinoi Takao, Kuroda Shintaro, Adachi Tomohiro, Kawaguchi Yasuo, Sasada Tatsunari, Takakura Yuji, Egi Hiroyuki, Okajima Masazumi, Tashiro Hirotaka, Nishizaka Takashi, Ohdan Hideki

Abstract excerpt

BACKGROUND: Hypoxia inducible factor-1α (HIF-1α) is a major regulator of tumorigenesis in hypoxic conditions and therefore represents a potential therapeutic target in colorectal cancer (CRC). Clinical significance of HIF-1α expression in liver metastases has not been elucidated. Therefore, this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23748663
DOI: 10.1245/s10434-013-2945-2

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23748663-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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