Article

HHIP protein interactions in lung cells provide insight into COPD pathogenesis

2024-04-01

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. The primary causes of COPD are environmental, including cigarette smoking; however, genetic susceptibility also contributes to COPD risk. Genome-Wide Association Studies (GWASes) have revealed more than 80 genetic loci associated with COPD, leading to the identification of multiple COPD GWAS genes. However, the biological r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7e6ccd1-3dce-5282-8ef3-02c4030154ea
DOI: 10.1101/2024.04.01.586839

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HHIP protein interactions in lung cells provide insight into COPD pathogenesisDOI 10.1101/2024.04.01.586839Read

HHIP protein interactions in lung cells provide insight into COPD pathogenesis.Semantic proximity Read

Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissueSemantic proximity Read

Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals.Semantic proximity Read

Integration of lung tissue proteomics and genome-wide association data to identify lung cancer susceptibility proteins and potential drug targetsSemantic proximity Read

Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancerSemantic proximity Read

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network ModuleSemantic proximity Read

Analysis of protein-protein interaction network in chronic obstructive pulmonary disease.Semantic proximity Read

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network ModuleSemantic proximity Read

Breathing new life into the study of COPD with genes identified from genome-wide association studies.Semantic proximity Read

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiringSemantic proximity Read

Hub Genes PRPF19 and PPIB: Molecular Pathways and Potential Biomarkers in COPD.Semantic proximity Read

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cellsSemantic proximity Read