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Article

Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells

27 Feb 2024

Abstract excerpt

BACKGROUND: An intergenic region at chromosome 4q31 is one of the most significant regions associated with COPD susceptibility and lung function in GWAS. In this region, the implicated causal gene HHIP has a unique epithelial expression pattern in adult human lungs, in contrast to dominant expression in fibroblasts in murine lungs. However, the mechanism underlying the species-dependent cell type-specific...

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PMID: 38417378
DOI: 10.1016/j.ebiom.2024.105026

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