Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HHIP protein interactions in lung cells provide insight into COPD pathogenesis.

Human molecular genetics - 17 Apr 2025

Deritei Dávid, Inuzuka Hiroyuki, Castaldi Peter J, Yun Jeong Hyun, Xu Zhonghui, Anamika Wardatul Jannat, Asara John M, Guo Feng, Zhou Xiaobo, Glass Kimberly, Wei Wenyi, Silverman Edwin K

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. The primary causes of COPD are environmental, including cigarette smoking; however, genetic susceptibility also contributes to COPD risk. Genome-Wide Association Studies (GWASes) have revealed more than 80 genetic loci associated with COPD, leading to the identification of multiple COPD GWAS genes. However, the biological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Membrane Glycoproteins

Share to Protein Interaction Maps

Share to Pulmonary Disease, Chronic Obstructive

Source

Open in PubMed Open full text

Identifiers

PMID: 39945347
DOI: 10.1093/hmg/ddaf016
PMCID: PMC12037150

Genes

HHIP
CAVIN1
TP53
DSP
FBLN5
MFAP2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HHIP protein interactions in lung cells provide insight into COPD pathogenesis.PMID 39945347Read ↗

HHIP protein interactions in lung cells provide insight into COPD pathogenesisSemantic proximity Read ↗

Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals.Semantic proximity Read ↗

Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissueSemantic proximity Read ↗

Integration of lung tissue proteomics and genome-wide association data to identify lung cancer susceptibility proteins and potential drug targetsSemantic proximity Read ↗

Analysis of protein-protein interaction network in chronic obstructive pulmonary disease.Semantic proximity Read ↗

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network ModuleSemantic proximity Read ↗

Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network ModuleSemantic proximity Read ↗

Hub Genes PRPF19 and PPIB: Molecular Pathways and Potential Biomarkers in COPD.Semantic proximity Read ↗

Breathing new life into the study of COPD with genes identified from genome-wide association studies.Semantic proximity Read ↗

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiringSemantic proximity Read ↗

Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic AnalysisSemantic proximity Read ↗

Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.