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Article

Partial correlation network analysis identifies coordinated gene expression within a regional cluster of COPD genome-wide association signals.

PLoS computational biology - 1 Oct 2024

Gentili Michele, Glass Kimberly, Maiorino Enrico, Hobbs Brian D, Xu Zhonghui, Castaldi Peter J, Cho Michael H, Hersh Craig P, Qiao Dandi, Morrow Jarrett D, Carey Vincent J, Platig John, Silverman Edwin K

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by well-established environmental exposures (most notably, cigarette smoking) and incompletely defined genetic factors. The chromosome 4q region harbors multiple genetic risk loci for COPD, including signals near HHIP, FAM13A, GSTCD, TET2, and BTC. Leveraging RNA-Seq data from lung tissue in COPD cases and controls, we estimated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39418301
DOI: 10.1371/journal.pcbi.1011079
PMCID: PMC11521246

Genes

BTC
HHIP
FAM13A
NPNT
TET2
PPM1K
GSTCD
PPA2
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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