Article

Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis

2022-06-08

Abstract excerpt

<title>Abstract</title> <p>The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the <italic>BCR</italic> gene located on chromosome 9q34 and the <italic>ABL1</italic> gene located on chromosome 22q11. Thus, mimicking the initiation process of translocation, we induced CRISPR/Cas9-medi...

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Literature Corpus work: b7d1da93-56da-598a-87be-493e8703c8bf
DOI: 10.21203/rs.3.rs-1437317/v1

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