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The Philadelphia chromosome in leukemogenesis

27 May 2016

Abstract excerpt

The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stability. This aberrant fusion gene encodes the breakpoint cluster region-proto-oncogene tyrosine-protein kinase (BCR-ABL1)...

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PMID: 27233483
DOI: 10.1186/s40880-016-0108-0

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