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Article

RNA toxicity in non-coding repeat expansion disorders.

The EMBO journal - 2 Jan 2020

Swinnen Bart, Robberecht Wim, Van Den Bosch Ludo

Abstract excerpt

Several neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia (SCA) are caused by non-coding nucleotide repeat expansions. Different pathogenic mechanisms may underlie these non-coding repeat expansion disorders. While gain-of-function mechanisms, such as toxicity associated with expression of repeat RNA or toxicity associated with repeat-associated non-ATG (RAN)...

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Identifiers

PMID: 31721251
DOI: 10.15252/embj.2018101112
PMCID: PMC6939197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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