Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses.

doi:10.1371/journal.ppat.1011135

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses.

PLoS pathogens - 1 Feb 2023

Scheibner David, Salaheldin Ahmed H, Bagato Ola, Zaeck Luca M, Mostafa Ahmed, Blohm Ulrike, Müller Christin, Eweas Ahmed F, Franzke Kati, Karger Axel, Schäfer Alexander, Gischke Marcel, Hoffmann Donata, Lerolle Solène, Li Xuguang, Abd El-Hamid Hatem S, Veits Jutta, Breithaupt Angele, Boons Geert-Jan, Matrosovich Mikhail, Finke Stefan, Pleschka Stephan, Mettenleiter Thomas C, de Vries Robert P, Abdelwhab Elsayed M

Abstract excerpt

Global spread and regional endemicity of H5Nx Goose/Guangdong avian influenza viruses (AIV) pose a continuous threat for poultry production and zoonotic, potentially pre-pandemic, transmission to humans. Little is known about the role of mutations in the viral neuraminidase (NA) that accompanied bird-to-human transmission to support AIV infection of mammals. Here, after detailed analysis of the NA sequence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chickens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferrets

Share to Influenza A virus

Share to Influenza A Virus, H5N1 Subtype

Share to Influenza, Human

Share to Influenza in Birds

Share to Mice

Share to Neuraminidase

Source

Open in PubMed Open full text

Identifiers

PMID: 36745654
DOI: 10.1371/journal.ppat.1011135
PMCID: PMC9934401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses.PMID 36745654Read ↗

Evolution and Adaptation of the Avian H7N9 Virus into the Human HostSemantic proximity Read ↗

Phenotypic Effects of Substitutions within the Receptor Binding Site of Highly Pathogenic Avian Influenza H5N1 Virus Observed during Human InfectionSemantic proximity Read ↗

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antiviralsSemantic proximity Read ↗

Characterization of H5N1 influenza virus variants with hemagglutinin mutations isolated from patients.Semantic proximity Read ↗

Comprehensive Evolutionary and Structural Analysis of the H5N1 Clade 2.4.3.4b Influenza a Virus Based on the Sequences and Data Mining of the Hemagglutinin, Nucleoprotein, and Neuraminidase Genes Across Multiple HostsSemantic proximity Read ↗

Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin.Semantic proximity Read ↗

Mutations in PB1, NP, HA, and NA Contribute to Increased Virus Fitness of H5N2 Highly Pathogenic Avian Influenza Virus Clade 2.3.4.4 in ChickensSemantic proximity Read ↗

A Closer Look at the NS1 of Influenza VirusSemantic proximity Read ↗

Preparedness, prevention and control related to zoonotic avian influenzaSemantic proximity Read ↗

A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice.Semantic proximity Read ↗

In Silico Prediction and Experimental Confirmation of HA Residues Conferring Enhanced Human Receptor Specificity of H5N1 Influenza A Viruses.Semantic proximity Read ↗

Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.