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Article

The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans.

PLoS pathogens - 1 Dec 2021

Grassmann André A, Zavala-Alvarado Crispin, Bettin Everton B, Picardeau Mathieu, Benaroudj Nadia, Caimano Melissa J

Abstract excerpt

Leptospira interrogans, the causative agent of most cases of human leptospirosis, must respond to myriad environmental signals during its free-living and pathogenic lifestyles. Previously, we compared L. interrogans cultivated in vitro and in vivo using a dialysis membrane chamber (DMC) peritoneal implant model. From these studies emerged the importance of genes encoding the Peroxide responsive regulators PerRA...

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Identifiers

PMID: 34855918
DOI: 10.1371/journal.ppat.1009078
PMCID: PMC8638967

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