Article

Beyond copy number: The regulatory architecture of mitochondrial DNA gene expression

2026-05-30

Abstract excerpt

Mitochondrial DNA (mtDNA) copy number is widely used as a biomarker for mitochondrial function and disease risk, yet its relationship to mtDNA gene expression – one important functional output – remains poorly understood. Prior studies examining this relationship have largely relied on heterogeneous tissue samples, where confounding by cell-type composition obscures the underlying biology. We rigorously tested thi...

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Literature Corpus work: b738365a-0d35-5d2a-b22c-73832729de73
DOI: 10.64898/2026.05.27.728277

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