Article

Interplay between mitochondrial and nuclear DNA in gene expression regulation

2024-12-10

Abstract excerpt

Using data from 48 tissues and 684 European individuals in the GTEx dataset, we investigate the role of mitochondrial DNA (mtDNA) and its encoded genes in gene regulation. We perform a comprehensive multi-tissue eQTL analysis on mtDNA encoded protein-coding genes, identifying 111 mtDNA-cis-eQTLs (FDR<5%) and 260 nucDNA trans-eQTLs (P<5×10 −8 ). We further identify 108 mtDNA associations with 68 nucDNA encoded gen...

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Literature Corpus work: d546a347-01af-5882-9fe2-4cbf895e4b02
DOI: 10.1101/2024.12.10.627680

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