Article

Energy-Starved Inflammation in Autism: Failure of Glycolytic Compensation Under IL-10–Driven Metabolic Tolerance

2025-12-24

Abstract excerpt

<title>Abstract</title> <p>Immune activation and metabolic reprogramming are hallmarks of inflammation, yet their coordination in autism spectrum disorder (ASD) remains poorly understood. Here, we introduce the τ-axis, a transcriptomic systems framework that quantifies immune-driven metabolic demand relative to cellular energy-producing capacity, and apply it to whole-blood cohorts from ASD and acute sepsis. Appl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b736b689-4bae-5926-896e-92965ebc2f4c
DOI: 10.21203/rs.3.rs-8390063/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Energy-Starved Inflammation in Autism: Failure of Glycolytic Compensation Under IL-10–Driven Metabolic ToleranceDOI 10.21203/rs.3.rs-8390063/v1Read

The Energy-Deficit Hypothesis of Autism: Multi-Cytokine Convergence on Mitochondrial Dysfunction: A Cerebral Energy-Deficit Hypothesis of Autism Spectrum DisorderSemantic proximity Read

Metabolic and Inflammatory Dysregulation in Autism Spectrum Disorder and COVID-19: A Hypothesis-Generating ReviewSemantic proximity Read

Endocrine-Microbial Trade-offs under Extreme Cold and Physical Stress: Multi-omics Network Reveals Tryptophan/Lipid Reprogramming and the Cost of Cortisol OverloadSemantic proximity Read

Cross-Disease Mapping of Immune Polarization and Metabolic DemandSemantic proximity Read

A Systems Hypothesis of Lipopolysaccharide-Induced Vitamin Transport Suppression and Metabolic Reprogramming in Autism Spectrum Disorders: An Open Call for Validation and Therapeutic TranslationSemantic proximity Read

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without SepsisSemantic proximity Read

Cellular allostatic load is linked to increased energy expenditure and accelerated biological agingSemantic proximity Read

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological AgingSemantic proximity Read

The flux of energy in critical illness and the obesity paradoxSemantic proximity Read

Developmental Bioenergetic Reprogramming and Glycolytic Shift in Schizophrenia VulnerabilitySemantic proximity Read

Comparative Enzymatic Profiling of Enteric vs. Cortical Neural Stem Cells: Establishing a Methodological Foundation for Modeling Enteric NeurodegenerationSemantic proximity Read

Energy Allocation Resilience and Endocrine IntegrationSemantic proximity Read