Article

A Systems Hypothesis of Lipopolysaccharide-Induced Vitamin Transport Suppression and Metabolic Reprogramming in Autism Spectrum Disorders: An Open Call for Validation and Therapeutic Translation

2025-05-12

Abstract excerpt

Autism Spectrum Disorder (ASD) is a clinically heterogeneous neurodevelopmental condition increasingly linked to systemic metabolic dysfunction. In this study, we applied a transcriptomics-based systems framework—Personalized Metabolic Margin Mapping (PM³) - to analyze prefrontal cortex samples from 12 individuals with ASD and 12 neurotypical controls. Differential expression of 158 curated metabolic genes was ass...

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Literature Corpus work: a510bd08-dbbb-5f3e-b565-9f16d9f33b45
DOI: 10.20944/preprints202505.0771.v1

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