Article

Therapeutic potential of oxygen through M101 transportation in reducing vaso-occlusion and hemolysis in a mouse model of sickle cell disease

2025-06-24

Abstract excerpt

Sickle cell disease (SCD) is a genetic disorder marked by hemoglobin S–induced red blood cell (RBC) sickling, causing hemolysis, vaso-occlusion, and organ damage. Despite its severity, treatment options remain limited. RBC transfusion is a highly effective therapeutic option in SCD, particularly due to its capacity to improve oxygen delivery and reduce sickling by introducing healthy red blood cells, but it is ass...

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Literature Corpus work: b70a3430-0458-57f7-b825-3821a007d796
DOI: 10.1101/2025.06.18.660442

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