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Article

Ferroptosis as an emerging target in sickle cell disease

1 Jan 2024

Abstract excerpt

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood cell sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of cell death characterized by reactive oxygen species (ROS) and lipid peroxide accumulation, leading to damage and organ impairments. The...

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PMID: 39021403
DOI: 10.1016/j.crtox.2024.100181

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