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Therapeutics for sickle cell disease intravascular hemolysis

13 Sept 2024

Abstract excerpt

Sickle cell disease (SCD) is a genetic disorder predominantly affecting individuals of African descent, with a significant global health burden. SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity. Clinical manifestations include acute pain crises, hemolytic anemia, and...

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Share to Erythrocyte Function and Pathophysiology
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PMID: 39345787
DOI: 10.3389/fphys.2024.1474569

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