Article

Convergent Usage of Amino Acids in Human Cancers as a Reversed Process of Tissue Development

2021-03-20

Abstract excerpt

Genome and transcriptome-wide amino acid usage preference across different species is a well-studied phenomenon in molecular evolution, but its characteristics and implication in cancer evolution and therapy remain largely unexplored. Here, we analyzed large-scale transcriptome/proteome profiles such as TCGA, GTEx, and CPTAC and found that compared to normal tissues, different cancer types showed a convergent patt...

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Literature Corpus work: b700d554-958d-5509-8508-348cf625d10a
DOI: 10.1101/2021.03.18.436083

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