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Innate Immunity in Pluripotent Human Cells

19 Apr 2013

Abstract excerpt

Type I interferon (IFN-α/β) binds to cell surface receptors IFNAR1 and IFNAR2 and triggers a signaling cascade that leads to the transcription of hundreds of IFN-stimulated genes. This response is a crucial component in innate immunity in that it establishes an "antiviral state" in cells and protects them against further damage. Previous work demonstrated that, compared with their differentiated counterparts,...

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PMID: 23599426
DOI: 10.1074/jbc.m112.435461

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