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Article

Do thrifty genes exist? Revisiting uricase.

Obesity (Silver Spring, Md.) - 1 Oct 2022

Johnson Richard J, Sánchez-Lozada Laura G, Nakagawa Takahiko, Rodriguez-Iturbe Bernardo, Tolan Dean, Gaucher Eric A, Andrews Peter, Lanaspa Miguel A

Abstract excerpt

Sixty years ago, the geneticist James Neel proposed that the epidemics of obesity and diabetes today may have evolutionary roots. Specifically, he suggested that our ancestors may have accumulated mutations during periods of famine that provided a survival advantage at that time. However, the presence of this "thrifty genotype" in today's world, where food is plentiful, would predispose us to obesity and...

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Identifiers

PMID: 36150210
DOI: 10.1002/oby.23540
PMCID: PMC9512363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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