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Pharmacological agents targeting drug-tolerant persister cells in cancer

1 Apr 2024

Abstract excerpt

Current cancer therapy can be effective, but the development of drug resistant disease is the usual outcome. These drugs can eliminate most of the tumor burden but often fail to eliminate the rare, "Drug Tolerant Persister" (DTP) cell subpopulations in residual tumors, which can be referred to as "Persister" cells. Therefore, novel therapeutic agents specifically targeting or preventing the development of...

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PMID: 38569982
DOI: 10.1016/j.phrs.2024.107163

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