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Article

Immunoglobulin gene polymorphisms shape the naïve B-cell receptor repertoire; relevance to celiac disease.

Genes and immunity - 1 Apr 2026

Officer Aengus, Watson Corey T, Engelbrecht Eric, Dahal-Koirala Shiva, Risnes Louise F, Lundin Knut E A, Ness-Jensen Eivind, Lindeman Ida, Sollid Ludvig M

Abstract excerpt

Genetic variation in the loci encoding immunoglobulin genes (IGH, IGK and IGL) affects the repertoire of B-cell receptors (BCRs). Such effects were previously demonstrated for total peripheral blood B cells, but so far have not been investigated at scale for isolated naïve B cells. As B cells are implicated in the pathogenesis of autoimmune diseases, genetically encoded features of the naïve BCR repertoire may...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41748905
DOI: 10.1038/s41435-026-00384-4

Genes

BCR
IGH
IGK
IGL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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