Article

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry Inhibitors

2018-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Lassa virus (LASV) belongs to the Mammarenavirus genus (family Arenaviridae ) and causes severe hemorrhagic fever in humans. At present, there are no Food and Drug Administration (FDA)-approved drugs or vaccines specific for LASV. Herein, high-throughput screening of an FDA-approved drug library was performed against LASV entry using a pseudo-type virus enveloping LASV glycoproteins. Two hit d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6970b21-3038-5a29-9547-8c9cb3773253
DOI: 10.1101/298463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry InhibitorsDOI 10.1101/298463Read

Screening of Botanical Drugs Against Lassa Virus EntrySemantic proximity Read

Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2Semantic proximity Read

Entry inhibitors as arenavirus antiviralsSemantic proximity Read

Drug discovery technologies and strategies for Machupo virus and other New World arenavirusesSemantic proximity Read

Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell InteractionSemantic proximity Read

Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1.Semantic proximity Read

Dual inhibition of vacuolar ATPase and TMPRSS2 is required for complete blockade of SARS-CoV-2 entry into cellsSemantic proximity Read

Repurposing Cilnidipine as an Entry Inhibitor Against Crimean–Congo Haemorrhagic Fever Pseudovirus InfectionSemantic proximity Read

Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenavirusesSemantic proximity Read

Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World ArenavirusesSemantic proximity Read

Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA VirusesSemantic proximity Read

The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural progenitor cellsSemantic proximity Read