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Article

Critical role for cholesterol in Lassa fever virus entry identified by a novel small molecule inhibitor targeting the viral receptor LAMP1.

PLoS pathogens - 1 Sept 2018

Wang May Kwang-Mei, Ren Tao, Liu Hu, Lim Sun-Young, Lee Kyungae, Honko Anna, Zhou Huanying, Dyall Julie, Hensley Lisa, Gartin Ashley K, Cunningham James M

Abstract excerpt

Lassa fever virus (LASV) is endemic in West Africa and causes severe hemorrhagic fever and sensorineural hearing loss. We identified a small molecule inhibitor of LASV and used it to analyze the mechanism of entry. Using a photo-reactive analog that retains antiviral activity as a probe, we identified the inhibitor target as lysosome-associated membrane protein 1 (LAMP1), a host factor that binds to the LASV...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Virus

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Source

Open in PubMed Open full text

Identifiers

PMID: 30265711
DOI: 10.1371/journal.ppat.1007322
PMCID: PMC6179309

Genes

LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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