Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses

19 May 2012

Abstract excerpt

INTRODUCTION: Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates. To date, at least 1,200 cases with ≈200 fatalities...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacillus and Francisella bacterial research
Share to Viral Infections and Outbreaks Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22607481
DOI: 10.1517/17460441.2012.687719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug discovery technologies and strategies for Machupo virus and other New World arenavirusesPMID 22607481Read ↗

Entry inhibitors as arenavirus antiviralsSemantic proximity Read ↗

Review of Mammarenavirus Biology and ReplicationSemantic proximity Read ↗

Human Hemorrhagic Fever Causing Arenaviruses: Molecular Mechanisms Contributing to Virus Virulence and Disease PathogenesisSemantic proximity Read ↗

Host Cell Factors as Antiviral Targets in Arenavirus InfectionSemantic proximity Read ↗

Recombinant Pichinde reporter virus as a safe and suitable surrogate for high-throughput antiviral screening against highly pathogenic arenavirusesSemantic proximity Read ↗

Development of reverse genetic tools to study Chapare and Machupo virusesSemantic proximity Read ↗

A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous GlycoproteinsSemantic proximity Read ↗

Junín Virus Promotes Autophagy To Facilitate the Virus Life CycleSemantic proximity Read ↗

The Virus–Host Interplay in Junín Mammarenavirus InfectionSemantic proximity Read ↗

Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis InhibitorSemantic proximity Read ↗

Arenaviruses and hantaviruses: From epidemiology and genomics to antiviralsSemantic proximity Read ↗

Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenavirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.