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Article

Different Mechanisms of Cell Entry by Human-Pathogenic Old World and New World Arenaviruses

29 May 2008

Abstract excerpt

The Old World arenavirus Lassa virus (LASV) is the causative agent of severe viral hemorrhagic fever (VHF) in humans and is the most prevalent human pathogen among arenaviruses. The present study investigated the largely unknown mechanisms of cell entry of LASV, a process know to be mediated solely by the virus envelope glycoprotein (GP). To circumvent biosafety restrictions associated with the use of live LASV,...

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Identifiers

PMID: 18508885
DOI: 10.1128/jvi.00560-08

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