Article

Rationally Designed PKD1 Activator Protects Against Neurodegeneration in Pre-clinical Models of Parkinson’s Disease

2025-02-21

Abstract excerpt

Oxidative stress leads to degeneration in Parkinson’s disease (PD). The key signal transduction and regulatory networks that are involved during this degenerative process in PD are currently being investigated for novel neuro-protective strategies. We recently discovered that the activation of Protein Kinase D1 (PKD1) acts as a novel compensatory mechanism in PD models and positive modulation of PKD1 can be a ther...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 974b5cc4-6ed4-53ed-840c-f3a29bd9360a
DOI: 10.1101/2025.02.13.637661

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rationally Designed PKD1 Activator Protects Against Neurodegeneration in Pre-clinical Models of Parkinson’s DiseaseDOI 10.1101/2025.02.13.637661Read

Advancing Parkinson’s Disease Biopathlogy and Drug Discovery by Dual Cellular ModelingSemantic proximity Read

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsSemantic proximity Read

MicroRNA-26a/Death-Associated Protein Kinase 1 Signaling Induces Synucleinopathy and Dopaminergic Neuron Degeneration in Parkinson’s DiseaseSemantic proximity Read

Protein Kinases and Parkinson’s DiseaseSemantic proximity Read

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsSemantic proximity Read

Teaching the basics of repurposing mitochondria-targeted drugs: From Parkinson's disease to cancer and back to Parkinson's diseaseSemantic proximity Read

Mitoxantrone Hydrochloride Targets APP and LRRK2 to Improve Neurodegeneration in Parkinson’s ModelsSemantic proximity Read

The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson’s diseaseSemantic proximity Read

Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson’s Disease ModelSemantic proximity Read

PKB/AKT attenuates Lewy Body-like pathology in primary neurons via Cathepsins B and DSemantic proximity Read

The potential applications of traditional Chinese medicine in Parkinson's disease: A new opportunitySemantic proximity Read

PKD1-tau disulfide linkage promotes tau phosphorylation and tau accumulation in a tauopathy mouse modelSemantic proximity Read