Article

Vascular and Lymphatic Dysregulation via Non-EndoMT <i>Col2a1</i> Signaling in Bisphosphonate-Related Osteonecrosis of the Jaw

2025-09-29

Abstract excerpt

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most severe complications of antiresorptive therapy. Although impaired angiogenesis is commonly observed in BRONJ, the underlying vascular mechanisms remain poorly understood, impeding the development of effective treatments. In this study, we integrated whole-organ tissue-clearing imaging, single-cell transcriptomics, and proteomics to construc...

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Literature Corpus work: 48f3be9a-448b-5cbc-934e-f984e1c8ee5b
DOI: 10.1101/2025.09.27.678999

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Vascular and Lymphatic Dysregulation via Non-EndoMT <i>Col2a1</i> Signaling in Bisphosphonate-Related Osteonecrosis of the JawDOI 10.1101/2025.09.27.678999Read

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